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The Results

introduction

The studies behind HAVA ZINGBOIM Skin Tech’s Prophecy and Remicronized product lines are pivotal in validating the groundbreaking technological innovations these products bring to the skincare industry. Both series incorporate novel methods for delivering key active ingredients—hyaluronic acid (HA) and collagen—deep into the skin layers, enhancing their efficacy. The clinical trials and scientific methods behind these products focus on exploring the depth of penetration, biological activity, and long-term effects, and have been key to establishing their success.

Prophecy Series

Hyaluronic Acid Delivery Technology

The primary challenge in skincare has always been the efficient delivery of active ingredients to the deeper layers of the skin, where they can exert their maximum effect. Hyaluronic acid, due to its large molecular size, has historically struggled with this issue. Although HA is a natural substance in the body that retains moisture and provides volume to the skin, it has a limited ability to penetrate the skin’s outer layer (stratum corneum) when applied topically.

Development of Micro-Size 
Hyaluronic Acid

HAVA ZINGBOIM research team, in collaboration with Professor Rachel Lubert and the Department of Chemistry, Physics, and Nanotechnology at Bar-Ilan University, focused on developing a delivery system that would preserve the molecular size of hyaluronic acid at a micro-level, even when incorporated into a cream formulation. This breakthrough
formula allowed the HA molecules to penetrate the skin effectively, where they could provide their maximum benefits.

Clinical and Scientific Findings

FDA-Approved Laboratory Studies

To test the efficacy of this breakthrough, clinical trials were conducted in FDA-approved laboratories, and the results were published in prestigious dermatological journals. The clinical studies showed that the Prophecy series’ HA not only maintained its moisture-retaining properties but also exhibited enhanced antioxidant capabilities. This unique formulation demonstrated an ability to deliver superior hydration and significantly improve skin elasticity and the appearance of fine lines.

Key findings from these studies include:

  • Increased Moisture Retention: The ability of the Prophecy series to hold moisture in the skin was doubled compared to traditional HA-based products. This resulted in a significantly more hydrated and plump appearance, which is vital for skin aging.
  • Antioxidant Properties: The advanced formulation amplified the antioxidant effects of HA, which are essential in combating oxidative stress—one of the key contributors to premature skin aging.
  • Visible Skin Improvements: Clinically, participants showed notable improvements in skin elasticity and a reduction in fine lines, reinforcing the effectiveness of the product.

The efficacy of the Prophecy line is not just a cosmetic improvement but is scientifically validated by measurable clinical data that demonstrate how the products go beyond surface-level results to deliver profound, long-lasting skin benefits.

Remicronized Series

Collagen Innovation

The Remicronized series represents the next level of scientific innovation by incorporating micronized collagen alongside hyaluronic acid. This dual technology addresses two of the most common challenges in skincare: collagen loss and inefficient delivery of active ingredients. Collagen plays a crucial role in maintaining the skin’s strength, firmness, and elasticity. As we age, the natural production of collagen in the skin declines, leading to the formation of wrinkles, loss of skin volume, and reduced elasticity.

Collagen Penetration and Micronization Technology
Traditional collagen in skincare products often fails to provide significant benefits because collagen molecules are too large to penetrate the skin’s outer barrier. Hydrolyzed collagen, which is broken into smaller peptides, has been used as an alternative, but it lacks the full structural benefits of intact collagen.

HAVA ZINGBOIM breakthrough in collagen delivery lies in the micronization process, which reduces the collagen fibers to a small enough size while preserving their structural integrity. This enables the collagen to penetrate deeply into the skin, where it can support the skin’s natural regeneration process and restore its firmness, elasticity, and hydration.

Clinical and Scientific Findings

Micronized Collagen Penetration

In-depth studies were conducted to analyze the penetration depth of the micronized collagen in the Remicronized series. Using advanced techniques such as Iterative Multiplane Optical Property Extraction (IMOPE), scientists were able to monitor how deeply the collagen particles penetrated the skin layers. These studies revealed that the collagen was able to reach the stratum corneum, the outermost layer of the skin, and even penetrate the deeper epidermal layers.

Key findings include:

  • Effective Collagen Penetration: The micronized collagen cream was shown to penetrate both the outer and deeper epidermal layers of the skin, a feat previously unattainable by traditional collagen-based skincare treatments.
  • Restoration of Skin Structure: The micronized collagen’s ability to penetrate deeply allowed it to restore skin structure from the inside out. Collagen is integral to maintaining skin firmness, strength, and elasticity, and the successful penetration of these collagen fibers led to measurable improvements in these parameters.
  • Antioxidant Activity: The collagen particles were also shown to exhibit antioxidant properties, reducing the presence of free radicals in the skin. This supports the skin’s natural defense system and helps to prevent the oxidative damage that accelerates the aging process.

Micronized Collagen Study

Methodology and Results

A comprehensive study was conducted to analyze the effectiveness of micronized collagen incorporated into a cream formulation. This study utilized environmental scanning electron microscopy (ESEM) and dynamic light scattering (DLS) techniques to assess the particle size of the micronized collagen. The study revealed that the collagen particles, once micronized, ranged between 120–200 nm in size, making them small enough to penetrate the skin while retaining their structural integrity.

Skin Surface Analysis

The study also employed optical profilometry to measure the roughness and smoothness of the skin after treatment with the collagen cream. The results showed significant improvements in skin texture, with smoother skin surfaces and reduced roughness, as indicated by key parameters like Sa (average surface roughness), Sz (maximum height of the surface), and Sp (peak height).

Penetration Depth

Using IMOPE, the study showed that micronized collagen particles were able to penetrate deeper into the skin than conventional collagen creams, reaching both the outermost and deeper layers of the epidermis. This result confirmed that micronized collagen could achieve the deep skin absorption necessary for real skin improvement.

 

Antioxidant Activity

The antioxidant effects of the micronized collagen were evaluated using electron paramagnetic resonance (EPR) spectroscopy, which tracks free radicals in the skin. The study found that the collagen particles significantly reduced the free radical activity in the skin, showcasing their powerful antioxidant capacity.

Clinical Efficacy Results

Enhanced Hydration, Firmness, and Skin Rejuvenation

 

  • 100%

    of participants reported more hydrated and moisturized skin, which demonstrates that the product significantly boosts skin hydration for everyone who tried it.

  • 94.55%

    of participants noticed firmer skin, with the majority of users feeling a noticeable improvement in the firmness and tautness of their skin.

  • 81.82%

    of participants observed a reduction in wrinkles and fine lines, suggesting that the product has anti-aging benefits.

  • 96.36%

    of participants were amazed by the results after 4 weeks, with almost all users reporting being impressed by how much their skin had improved over the course of the trial.

  • 96.36%

    of participants reported that their skin looked more radiant, indicating that the product has a brightening effect, helping skin look more youthful and glowing.

  • 96.36%

    of participants noted their skin appeared more vital and refreshed, suggesting a healthier, more rejuvenated appearance.

Conclusion

The clinical and scientific advancements behind the Prophecy and Remicronized product lines have set a new standard in skincare technology. Through groundbreaking innovations in hyaluronic acid delivery and collagen micronization, HAVA ZINGBOIM has succeeded in creating formulas that penetrate the skin more effectively than traditional products. These studies not only validate the effectiveness of these products but also demonstrate the potential for future advancements in skin rejuvenation. By combining nanotechnology with scientifically-backed clinical trials, HAVA ZINGBOIM has revolutionized how skincare products can rejuvenate the skin from within, offering a deeper, more long-lasting solution to skin aging.